HbxB Is a Key Regulator for Stress Response and β-Glucan Biogenesis in Aspergillus nidulans.

ABSTRACT: Homeobox transcription factors are conserved in eukaryotes and act as multi-functional transcription factors in filamentous fungi. Previously, it was demonstrated that HbxB governs fungal development and spore viability in Aspergillus nidulans. Here, the role of HbxB in A. nidulans was further characterized. RNA-sequencing revealed that HbxB affects the transcriptomic levels of genes associated with trehalose biosynthesis and response to thermal, oxidative, and radiation stresses in asexual spores called conidia. A phenotypic analysis found that hbxB deletion mutant conidia were more sensitive to ultraviolet stress. The loss of hbxB increased the mRNA expression of genes associated with β-glucan degradation and decreased the amount of β-glucan in conidia. In add

SUBMITTER: Son SH 

PROVIDER: S-EPMC7827800 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature