Circulating Extracellular Vesicles: The Missing Link between Physical Exercise and Depression Management?

ABSTRACT: Depression is associated with an increased risk of aging-related diseases. It is also seemingly a common psychological reaction to pandemic outbreaks with forced quarantines and lockdowns. Thus, depression represents, now more than ever, a major global health burden with therapeutic management challenges. Clinical data highlights that physical exercise is gaining momentum as a non-pharmacological intervention in depressive disorders. Although it may contribute to the reduction of systemic inflammation associated with depression, the mechanisms underlying the beneficial physical exercise effects in emotional behavior remain to be elucidated. Current investigations indicate that a rapid release of extracellular vesicles into the circulation might be the signaling mediators of systemic adapta

SUBMITTER: Soares E 

PROVIDER: S-EPMC7827999 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature