Anti-Trypanosoma cruzi Activity of Metabolism Modifier Compounds.

ABSTRACT: Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects over 6 million people worldwide. Development of new drugs to treat this disease remains a priority since those currently available have variable efficacy and frequent adverse effects, especially during the long regimens required for treating the chronic stage of the disease. T. cruzi modulates the host cell-metabolism to accommodate the cell cytosol into a favorable growth environment and acquire nutrients for its multiplication. In this study we evaluated the specific anti-T. cruzi activity of nine bio-energetic modulator compounds. Notably, we identified that 17-DMAG, which targets the ATP-binding site of heat shock protein 90 (Hsp90), has a very high (sub-micromolar range) selective inh

SUBMITTER: Martinez-Peinado N 

PROVIDER: S-EPMC7828178 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature