Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk.

ABSTRACT: Bone and muscle have been recognized as endocrine organs since they produce and secrete "hormone-like factors" that can mutually influence each other and other tissues, giving rise to a "bone-muscle crosstalk". In our study, we made use of myogenic (C2C12 cells) and osteogenic (2T3 cells) cell lines to investigate the effects of muscle cell-produced factors on the maturation process of osteoblasts. We found that the myogenic medium has inhibitory effects on bone cell differentiation and we identified sclerostin as one of the myokines produced by muscle cells. Sclerostin is a secreted glycoprotein reportedly expressed by bone/cartilage cells and is considered a negative regulator of bone growth due to its role as an antagonist of the Wnt/β-catenin pathway. Given the inhibitory role of scler

SUBMITTER: Magaro MS 

PROVIDER: S-EPMC7828203 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature