Dataset Information

Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth.

ABSTRACT: In animals, muscle growth is a quantitative trait controlled by multiple genes. Previously, we showed that the transient receptor potential channel 1 (TRPC1) gene was differentially expressed in muscle tissues between pig breeds with divergent growth traits base on RNA-seq. Here, we characterized TRPC1 expression profiles in different tissues and pig breeds and showed that TRPC1 was highly expressed in the muscle. We found two single nucleotide polymorphisms (SNPs) (C-1763T and C-1604T) in TRPC1 that could affect the promoter region activity and regulate pig growth rate. Functionally, we used RNAi and overexpression to illustrate that TRPC1 promotes myoblast proliferation, migration, differentiation, fusion, and muscle hypertrophy while inhibiting muscle degradation. These processes may be mediated by the activation of Wnt signaling pathways. Altogether, our results revealed that TRPC1 might promote muscle growth and development and plays a key role in Wnt-mediated myogenesis.

SUBMITTER: Fu Y

PROVIDER: S-EPMC7828378 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth.

Fu Yu Y Shang Peng P Zhang Bo B Tian Xiaolong X Nie Ruixue R Zhang Ran R Zhang Hao H

Cells 20210113 1

In animals, muscle growth is a quantitative trait controlled by multiple genes. Previously, we showed that the transient receptor potential channel 1 (TRPC1) gene was differentially expressed in muscle tissues between pig breeds with divergent growth traits base on RNA-seq. Here, we characterized TRPC1 expression profiles in different tissues and pig breeds and showed that TRPC1 was highly expressed in the muscle. We found two single nucleotide polymorphisms (SNPs) (C-1763T ...[more]

PMID: 33450983

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Dataset Information

Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth.

Publications

Function of the Porcine <i>TRPC1</i> Gene in Myogenesis and Muscle Growth.

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