Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery.

ABSTRACT: Four-arm star-shaped (denoted as 'S') polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N'-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as 'L') counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5-19.0% of DOX release at pH 7.4 and 77.6-78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy a

SUBMITTER: Wen W 

PROVIDER: S-EPMC7828523 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature