Indirect frontocingulate structural connectivity predicts clinical response to accelerated rTMS in major depressive disorder

ABSTRACT:

Background

Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), but its clinical efficacy remains rather modest. One reason for this could be that the propagation of rTMS effects via structural connections from the stimulated area to deeper brain structures (such as the cingulate cortices) is suboptimal.

Methods

We investigated whether structural connectivity — derived from diffusion MRI data — could serve as a biomarker to predict treatment response. We hypothesized that stronger structural connections between the patient-specific stimulation position in the left dorsolateral prefrontal cortex (dlPFC) and the cingulate cortices would predict better clinical outcomes. We applied accelerated intermittent theta bu

SUBMITTER: Klooster DC 

PROVIDER: S-EPMC7828925 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature