Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic review

ABSTRACT:

Background

Rett syndrome (RTT), a debilitating neuropsychiatric disorder that begins in early childhood, is characterized by impairments in the autonomic nervous system that can lead to sudden unexpected death. This study explores the mechanisms of autonomic dysfunction to identify potential risk factors for sudden death in patients with RTT.

Methods

Following the Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, we undertook comprehensive systematic reviews using the PubMed, Scopus, Cochrane, PsycINFO, Embase and Web of Science databases.

Results

We identified and critically appraised 39 articles for autonomic dysfunction and 5 for sudden death that satisfied the eligibility criteria. Following thematic analysis, we identified 7 themes: breat

SUBMITTER: Singh J 

PROVIDER: S-EPMC7828978 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature