CACNA1C polymorphism and brain cortical structure in bipolar disorder

ABSTRACT:

Background

The CACNA1C gene encodes the 1C subunit of L-type voltage-gated calcium channels and has been associated with several psychiatric syndromes — including bipolar disorder — in several genome-wide association studies. Experimental and clinical studies have reported changes with respect to behaviour and biomarkers in risk allele carriers, corroborating the essential role of the CACNA1C gene in neurons, during development and in the mature brain. However, the association of this gene with regional cortical thickness has not been evaluated in patients with bipolar disorder.

Methods

Using magnetic resonance imaging, we measured the average cortical thickness of 68 brain regions in 87 patients genotyped for the single-nucleotide polymorphism rs1006737 in CACNA1C.

Resul

SUBMITTER: Smedler E 

PROVIDER: S-EPMC7828982 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature