Statistical fundamentals on cancer research for clinicians: Working with your statisticians.

ABSTRACT:

Purpose

To facilitate understanding statistical principles and methods for clinicians involved in cancer research.

Methods

An overview of study design is provided on cancer research for both observational and clinical trials addressing study objectives and endpoints, superiority tests, non-inferiority and equivalence design, and sample size calculation. The principles of statistical models and tests including contemporary standard methods of analysis and evaluation are discussed. Finally, some statistical pitfalls frequently evident in clinical and translational studies in cancer are discussed.

Results

We emphasize the practical aspects of study design (superiority vs non-inferiority vs equivalence study) and assumptions underpinning power calculations and sample size

SUBMITTER: Xu W 

PROVIDER: S-EPMC7829109 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature