Strategies for Oligodendrocyte and Myelin Repair in Traumatic CNS Injury.

ABSTRACT: A major consequence of traumatic brain and spinal cord injury is the loss of the myelin sheath, a cholesterol-rich layer of insulation that wraps around axons of the nervous system. In the central nervous system (CNS), myelin is produced and maintained by oligodendrocytes. Damage to the CNS may result in oligodendrocyte cell death and subsequent loss of myelin, which can have serious consequences for functional recovery. Demyelination impairs neuronal function by decelerating signal transmission along the axon and has been implicated in many neurodegenerative diseases. After a traumatic injury, mechanisms of endogenous remyelination in the CNS are limited and often fail, for reasons that remain poorly understood. One area of research focuses on enhancing this endogenous response. Existing

SUBMITTER: Huntemer-Silveira A 

PROVIDER: S-EPMC7829188 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature