A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients.

ABSTRACT:

Background/objectives

Obesity appears to be an independent risk factor for ICU admission and a severe disease course in COVID-19 patients. An aberrant inflammatory response and impaired respiratory function have been suggested as underlying mechanisms. We investigated whether obesity is associated with differences in inflammatory, respiratory, and clinical outcome parameters in critically ill COVID-19 patients.

Subjects/methods

Sixty-seven COVID-19 ICU patients were divided into obese (BMI ≥ 30 kg/m², n = 18, 72% class I obesity, 28% class II obesity) and non-obese (BMI < 30 kg/m², n = 49) groups. Concentrations of circulating interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interferon gamma-induced protein

SUBMITTER: Kooistra EJ 

PROVIDER: S-EPMC7829495 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature