A comparative prognostic performance of definitions of Crohn-like lymphoid reaction in colorectal carcinoma.

ABSTRACT:

Background

The prognostic potential of Crohn-like lymphoid reaction (CLR) in colorectal carcinoma (CRC) has been investigated through the assessment of different criteria.

Methods

The prognostic impact of CLR was investigated in 636 CRC patients to compare methods from previously published articles. These methods included CLR measured by number of lymphoid aggregates (LAs) (CLR count), LA size greater than or equal to 1 mm (CLR size), CLR density with a cutoff value of 0.38, and subjective criteria as defined by intense CLR.

Results

In univariate survival analysis, CLR-positive CRC as defined by the four aforementioned methods was associated with better overall survival (OS) (hazard ratio [HR], 0.463; 95% confidence interval [CI], 0.305 to 0.702; p <.001; HR, 0.656; 9

SUBMITTER: Kim Y 

PROVIDER: S-EPMC7829571 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature