Modulation of Antigen Display on PapMV Nanoparticles Influences Its Immunogenicity.

ABSTRACT: The papaya mosaic virus (PapMV) vaccine platform is a rod-shaped nanoparticle made of the recombinant PapMV coat protein (CP) self-assembled around a noncoding single-stranded RNA (ssRNA) template. The PapMV nanoparticle induces innate immunity through stimulation of the Toll-like receptors (TLR) 7 and 8. The display of the vaccine antigen at the surface of the nanoparticle, associated with the co-stimulation signal via TLR7/8, ensures a strong stimulation of the immune response, which is ideal for the development of candidate vaccines. In this study, we assess the impact of where the peptide antigen is fused, whether at the surface or at the extremities of the nanoparticles, on the immune response directed to that antigen. Two different peptides from influenza A virus were used as model a

SUBMITTER: Laliberte-Gagne ME 

PROVIDER: S-EPMC7829862 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature