Effects of the Openness to Experience Polygenic Score on Cortical Thickness and Functional Connectivity.

ABSTRACT: Openness to experience (OTE) has relatively stable and heritable characteristics. Previous studies have used candidate gene approaches to explore the genetic mechanisms of OTE, but genome-wide polygenic scores have a greater genetic effect than other genetic analysis methods, and previous studies have never examined the potential effect of OTE on this cumulative effect at the level of the brain mechanism. In the present study, we aim to explore the associations between polygenic scores (PGSs) of OTE and brain structure and functions. First, the results of PGSs of OTE at seven different thresholds were calculated in a large Chinese sample (N = 586). Then, we determined the associations between PGSs of OTE and cortical thickness and functional connectivity. The results showed that PGS

SUBMITTER: Ren Z 

PROVIDER: S-EPMC7829912 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature