Passive Immunization with Recombinant Antibody VLRB-PirA^vp/PirB^vp-Enriched Feeds against Vibrio parahaemolyticus Infection in Litopenaeus vannamei Shrimp.

ABSTRACT: The causative agent of acute hepatopancreatic necrosis disease (AHPND) is the bacterium, Vibrio parahaemolyticus, which secretes toxins into the gastrointestinal tract of its host. Vibrio parahaemolyticus toxins A and B (PirA^vp/PirB^vp) have been implicated in the pathogenesis of this disease, and are, therefore, the focus of studies developing treatments for AHPND. We previously produced recombinant antibodies based on the hagfish variable lymphocyte receptor B (VLRB) capable of neutralizing some viruses, suggesting that this type of antibody may have a potential application for treatment of AHPND. Here, recombinant PirA^vp/PirB^vp, produced using a bacterial expression system, were used as antigens to screen a hagfish VLRB cDNA libra

SUBMITTER: Lazarte JMS 

PROVIDER: S-EPMC7829966 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature