Increased Circulating of CD54^highCD181^low Neutrophils in Myelodysplastic Syndrome.

ABSTRACT: Myelodysplastic syndromes (MDSs) are a group of heterogeneous hematopoietic stem/progenitor cells clonal diseases, characteristic features with myeloid dysplasia, leading to abnormality of neutrophils. Recent studied have showed that neutrophils act not only as professional killers, but also as regulators of innate and adaptive immune in infection and inflammatory condition. The CD54^highCD181^low neutrophils are a kind of reverse-transmigrated neutrophils characterized proinflammatory phenotype. We investigated the frequency and functional properties of circulating CD54^highCD181^low neutrophils in patients with untreated MDS. Frequency of CD54^highCD181^low neutrophils was significantly increased in MDS patients and related to t

SUBMITTER: Yang L 

PROVIDER: S-EPMC7830137 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature