P63 expression in human tumors and normal tissues: a tissue microarray study on 10,200 tumors.

ABSTRACT:

Background

Tumor protein 63 (p63) is a transcription factor of the p53 gene family involved in differentiation of several tissues including squamous epithelium. p63 immunohistochemistry is broadly used for tumor classification but published data on its expression in cancer is conflicting.

Methods

To comprehensively catalogue p63 expression, tissue microarrays (TMAs) containing 12,620 tissue samples from 115 tumor entities and 76 normal tissue types were analyzed.

Results

p63 expression was seen in various normal tissues including squamous epithelium and urothelium. At least occasional weak p63 positivity could be detected in 61 (53%) of 115 different tumor types. The frequencies of p63 positivity was highest in squamous cell carcinomas irrespective of their origin (96

SUBMITTER: Steurer S 

PROVIDER: S-EPMC7830855 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature