New Antineoplastic Naphthohydroquinones Attached to Labdane and Rearranged Diterpene Skeletons.

ABSTRACT: Terpenylquinones are mixed biogenesis primary or secondary metabolites widespread in Nature with many biological activities, including the antineoplastic cytotoxicity, that have inspired this work. Here, we present a cytotoxic structure-activity relationship of several diterpenylhydroquinone (DTHQ) derivatives, obtained from the natural labdane diterpenoid myrceocommunic acid used as starting material. Different structural modifications, that changed the functionality and stereochemistry of the decalin, have been implemented on the bicyclic core through epoxidation, ozonolysis or decarboxylation, and through induction of biomimetic breaks and rearrangements of the diterpene skeleton. All the isomers generated were completely characterized by spectroscopic procedures. The resulting compound

SUBMITTER: Hernandez AP 

PROVIDER: S-EPMC7831060 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature