Screening of disease-related biomarkers related to neuropathic pain (NP) after spinal cord injury (SCI).

ABSTRACT:

Background

Based on the molecular expression level, this paper compares lncRNA and mRNA expressions respectively in peripheral blood samples of the patients after SCI with NP and without NP, and screens disease-related biomarkers related to NP after SCI in peripheral blood samples of patients.

Method

The expression spectrum of 25 human peripheral blood samples (12 samples of refractory NP patients after SCI) was downloaded and data were normalized. Screening of GO annotations significantly associated with significant differentially expressed mRNAs and significant involvement of the KEGG pathway. The WGCNA algorithm was used to screen for modules and RNAs that were significantly associated with disease characterization. A co-expression network was constructed to extract the g

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7831171 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature