Impact of antipsychotics in children and adolescents with autism spectrum disorder: a systematic review and meta-analysis.

ABSTRACT:

Background

The net health benefit of using antipsychotics in children and adolescents with ASD is unclear. This review was performed to provide the evidence necessary to inform the Italian national guidelines for the management of ASD.

Methods

We performed a systematic review of randomized controlled trials (RCTs) comparing antipsychotics versus placebo for the treatment of ASD in children and adolescents. For efficacy, acceptability and safety we considered outcomes evaluated by the guideline panel critical and important for decision-making. Continuous outcomes were analyzed by using standardized mean difference (SMD), and dichotomous outcomes by calculating the risk ratio (RR), with their 95% confidence interval (95% CI). Data were analyzed using a random effects model. We

SUBMITTER: D'Alo GL 

PROVIDER: S-EPMC7831175 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature