Male obesity impacts DNA methylation reprogramming in sperm.

ABSTRACT:

Background

Male obesity has profound effects on morbidity and mortality, but relatively little is known about the impact of obesity on gametes and the potential for adverse effects of male obesity to be passed to the next generation. DNA methylation contributes to gene regulation and is erased and re-established during gametogenesis. Throughout post-pubertal spermatogenesis, there are continual needs to both maintain established methylation and complete DNA methylation programming, even during epididymal maturation. This dynamic epigenetic landscape may confer increased vulnerability to environmental influences, including the obesogenic environment, that could disrupt reprogramming fidelity. Here we conducted an exploratory analysis that showed that overweight/obesity (n = 20) is a

SUBMITTER: Keyhan S 

PROVIDER: S-EPMC7831195 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature