Metabolic dysfunction in pregnancy: Fingerprinting the maternal metabolome using proton nuclear magnetic resonance spectroscopy.

ABSTRACT:

Aims

Maternal metabolic disorders place the mother at risk for negative pregnancy outcomes with potentially long-term health impacts for the child. Metabolic syndrome, a cluster of features associated with increased risk of metabolic disorders, such as cardiovascular disease, diabetes and stroke, affects roughly one in five Canadians. Metabolomics is a relatively new technique that may be a useful tool to identify women at risk of metabolic disorders. This study set out to characterize urinary metabolic biomarkers of pregnant women with obesity and of pregnant women who later developed gestational diabetes mellitus (pre-GDM), compared to controls.

Methods and materials

Second trimester urine samples were collected through the Alberta Pregnancy Outcomes and Nutrition (APrON)

SUBMITTER: Scott HD 

PROVIDER: S-EPMC7831222 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature