Targeted eicosanoids profiling reveals a prostaglandin reprogramming in breast Cancer by microRNA-155.

ABSTRACT:

Background

Prostaglandin is one of the key metabolites for inflammation-related carcinogenesis. Despite the microRNA-155 is implicated in various types of cancers, it's function in prostaglandin metabolism is largely unknown.

Methods

A targeted profiling of eicosanoids including prostaglandin, leukotriene and thromboxanes was performed in miR-155 deficient breast tumors and cancer cells. The molecular mechanism of miR-155-mediated prostaglandin reprogramming was investigated in primary and cancer cell lines, by analyzing key enzymes responsible for the prostaglandin production.

Results

We found miR-155-deficient breast tumors, plasma of tumor-bearing mouse and cancer cells show altered prostaglandin level, especially for the prostaglandin E2 (PGE2) and prostaglandin D

SUBMITTER: Kim S 

PROVIDER: S-EPMC7831268 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature