Quantification of Nitric Oxide Concentration Using Single-Walled Carbon Nanotube Sensors.

ABSTRACT: Nitric oxide (NO), a free radical present in biological systems, can have many detrimental effects on the body, from inflammation to cancer. Due to NO's short half-life, detection and quantification is difficult. The inability to quantify NO has hindered researchers' understanding of its impact in healthy and diseased conditions. Single-walled carbon nanotubes (SWNTs), when wrapped in a specific single-stranded DNA chain, becomes selective to NO, creating a fluorescence sensor. Unfortunately, the correlation between NO concentration and the SWNT's fluorescence intensity has been difficult to determine due to an inability to immobilize the sensor without altering its properties. Through the use of a recently developed sensor platform, systematic studies can now be conducted to determine the

SUBMITTER: Meier J 

PROVIDER: S-EPMC7831316 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature