Reference Values for Hematology, Plasma Biochemistry, Bone Marrow Cytology and Bone Histology of NOD<i>.Cg-Prkdc^scid Il2rg^tm1Wjl/</i> SzJ Immunodeficient Mice.

ABSTRACT: Highly immunodeficient NSG mice (NOD.Cg-Prkdc^scid Il2rg^tm1Wjl/SzJ) are commonly used as a models in preclinical studies for patient-derived engraftment. However, despite the frequency of their use, reference values for their clinical pathology markers have not been determined. In accordance with the American Society of Veterinary Clinical Pathology (ASVCP) recommendations, we established de novo reference values for hematologic and biochemical variables and evaluated bone marrow cytology and histology in forty 9-wk-old male and female NSG mice. Hematologic analyses were performed using 2 separate analyzers (IDEXX ProCyte Dx, Sysmex XT-2000iV) and biochemical values were measured using a Scil VetScan2. The primary hematologic characteristic seen in NSG mice was

SUBMITTER: Layssol-Lamour CJ 

PROVIDER: S-EPMC7831346 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature