Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.

ABSTRACT:

Objective

To study messenger ribonucleic acid (mRNA) and protein expressions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry receptors (angiotensin 1-converting enzyme 2 [ACE2] and CD147) and proteases (transmembrane serine protease 2 [TMPRSS2] and cathepsin L [CTSL]) in human oocytes, embryos, and cumulus (CCs) and granulosa cells (GCs).

Design

Research study.

Setting

Clinical in vitro fertilization (IVF) treatment center.

Patients

Patients undergoing IVF were treated at the Colorado Center for Reproductive Medicine.

Interventions

Oocytes (germinal vesicle and metaphase II [MII]) and embryos (1-cell [1C] and blastocyst [BL]) were donated for research at the disposition by the patients undergoing IVF. Follicular cells (CC and GC) we

SUBMITTER: Rajput SK 

PROVIDER: S-EPMC7831752 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature