SARS-CoV-2 genomic characterization and clinical manifestation of the COVID-19 outbreak in Uruguay.

ABSTRACT: COVID-19 is a respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and declared by the World Health Organization a global public health emergency. Among the severe outbreaks across South America, Uruguay has become known for curtailing SARS-CoV-2 exceptionally well. To understand the SARS-CoV-2 introductions, local transmissions, and associations with genomic and clinical parameters in Uruguay, we sequenced the viral genomes of 44 outpatients and inpatients in a private healthcare system in its capital, Montevideo, from March to May 2020. We performed a phylogeographic analysis using sequences from our cohort and other studies that indicate a minimum of 23 independent introductions into Uruguay, resulting in five major transmission clusters. Our data s

SUBMITTER: Elizondo V 

PROVIDER: S-EPMC7832039 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature