Clinical Significance of the Correlation between Changes in the Major Intestinal Bacteria Species and COVID-19 Severity.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is a highly contagious infectious disease. Similar to H7N9 infection, pneumonia and cytokine storm are typical clinical manifestations of COVID-19. Our previous studies found that H7N9 patients had intestinal dysbiosis. However, the relationship between the gut microbiome and COVID-19 has not been determined. This study recruited a cohort of 57 patients with either general (n = 20), severe (n = 19), or critical (n = 18) disease. The objective of this study was to investigate changes in the abundance of ten predominant intestinal bacterial groups in COVID-19 patients using quantitative polymerase chain reaction (q-PCR), and to establish a correlation between these bacterial groups and clinical indicators of pneumonia in these patients

SUBMITTER: Tang L 

PROVIDER: S-EPMC7832131 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature