Manipulated bio antimicrobial peptides from probiotic bacteria as proposed drugs for COVID-19 disease.

ABSTRACT: Coronavirus disease 19 (COVID-19) is the latest pandemic resulted from the coronavirus family. Due to the high prevalence of this disease, its high mortality rate, and the lack of effective treatment, the need for affordable and accessible drugs is one of the main challenges in this regard. It has been proved that RdRp, 3CL, Spike, and Nucleocapsid are the most important viral proteins playing vital roles in the processes of proliferation and infection. Therefore, we started studying a wide range of bio-peptides and then conducted molecular docking analyses to investigate their binding affinity for the inhibition of these proteins. After obtaining the best bio-peptides with the highest affinity scores, they were examined for further study and then manipulated to eliminate their side effect

SUBMITTER: Balmeh N 

PROVIDER: S-EPMC7832255 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature