White Matter Microstructural Differences between Hallucinating and Non-Hallucinating Schizophrenia Spectrum Patients.

ABSTRACT: The relation between auditory verbal hallucinations (AVH) and white matter has been studied, but results are still inconsistent. This inconsistency may be related to having only a single time-point of AVH assessment in many studies, not capturing that AVH severity fluctuates over time. In the current study, AVH fluctuations were captured by utilizing a longitudinal design and using repeated (Positive and Negative Symptoms Scale) PANSS questionnaire interviews over a 12 month period. We used a Magnetic Resonance Diffusion Tensor Imaging (MR DTI) sequence and tract-based spatial statistics (TBSS) to explore white matter differences between two subtypes of schizophrenia patients; 44 hallucinating (AVH+) and 13 non-hallucinating (AVH-), compared to 13 AVH- matched controls and 44 AVH+ matched

SUBMITTER: Beresniewicz J 

PROVIDER: S-EPMC7832406 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature