Neurological involvement in SARS-CoV-2 infection: A clinical systematic review.

ABSTRACT:

Objective

Reports of neurological involvement during Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection course are increasingly described. The aim of this review is to provide a clinical approach of SARS-CoV-2 neurological complications based on the direct or indirect (systemic/immune-mediated) role of the SARS-CoV-2 in their genesis.

Methods

A review of the current literature has been carried out up to May 20th 2020 according to the PRISMA guidelines. All case series and reports of adult neurological manifestations associated to SARS-CoV-2 published in English were considered. Review and fundamental research studies on Coronaviruses neuroinvasive potential were analyzed to support pathogenic hypothesis and possible underlying mechanisms. Clinical pattern

SUBMITTER: Scoppettuolo P 

PROVIDER: S-EPMC7832728 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature