Metformin use is associated with a reduced risk of mortality in patients with diabetes hospitalised for COVID-19.

ABSTRACT:

Aims

Metformin exerts anti-inflammatory and immunosuppressive effects. We addressed the impact of prior metformin use on prognosis in patients with type 2 diabetes hospitalised for COVID-19.

Methods

CORONADO is a nationwide observational study that included patients with diabetes hospitalised for COVID-19 between March 10 and April 10, 2020 in 68 French centres. The primary outcome combined tracheal intubation and/or death within 7 days of admission. A Kaplan-Meier survival curve was reported for death up to day 28. The association between metformin use and outcomes was then estimated in a logistic regression analysis after applying a propensity score inverse probability of treatment weighting approach.

Results

Among the 2449 patients included, 1496 were metformin use

SUBMITTER: Lalau JD 

PROVIDER: S-EPMC7832745 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature