Transparency and Reproducibility of Observational Cohort Studies Using Large Healthcare Databases.

ABSTRACT: The scientific community and decision-makers are increasingly concerned about transparency and reproducibility of epidemiologic studies using longitudinal healthcare databases. We explored the extent to which published pharmacoepidemiologic studies using commercially available databases could be reproduced by other investigators. We identified a nonsystematic sample of 38 descriptive or comparative safety/effectiveness cohort studies. Seven studies were excluded from reproduction, five because of violation of fundamental design principles, and two because of grossly inadequate reporting. In the remaining studies, >1,000 patient characteristics and measures of association were reproduced with a high degree of accuracy (median differences between original and reproduction <2% and <0.1). An e

SUBMITTER: Wang SV 

PROVIDER: S-EPMC7833029 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature