The safety and efficacy of doxazosin in medical expulsion therapy for distal ureteric calculi: A meta-analysis.

ABSTRACT:

Purpose

Alpha-adrenergic receptor blockers can be effectively used in the context of medical expulsion therapy (MET) to treat ureteric stones. This study was designed to evaluate the safety and efficacy of doxazosin in MET relative to placebo or tamsulosin.

Methods

We systematically searched the PubMed, the Cochrane Library, EMBASE, Chinese Academic Database, and Web of Science databases to select randomized controlled trials (RCT) that compared the use of doxazosin with placebo or tamsulosin to treat ureteric stones. All patients we included were limited to those diagnosed with visible stones in the distal ureter. The diameter of ureteric stones does not exceed 10 mm.

Results

Eight trials comparing doxazosin with placebo or tamsulosin containing 667 patients were ass

SUBMITTER: Yu B 

PROVIDER: S-EPMC7833139 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature