Pupillary reflex and behavioral masking responses to light as functional measures of retinal degeneration in mice.

ABSTRACT:

Background

Pre-clinical testing of retinal pathology and treatment efficacy depends on reliable and valid measures of retinal function. The electroretinogram (ERG) and tests of visual acuity are the ideal standard, but can be unmeasurable while useful vision remains. Non-image-forming responses to light such as the pupillary light reflex (PLR) are attractive surrogates. However, it is not clear how accurately such responses reflect changes in visual capability in specific disease models. The purpose of this study was to test whether measures of non-visual responses to light correlate with previously determined visual function in two photoreceptor degenerations.

Methods

The sensitivity of masking behavior (light induced changes in running wheel activity) and the PLR were meas

SUBMITTER: Contreras EO 

PROVIDER: S-EPMC7833141 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature