Amianthoid transformation of costal cartilage matrix in children with pectus excavatum and pectus carinatum.

ABSTRACT:

Background

It is unclear if amianthoid transformation (AT) of costal cartilage extracellular matrix (ECM) has an impact on the development of pectus excavatum (PE) and pectus carinatum (PC).

Methods

AT foci were examined in intrasurgical biopsy specimens of costal cartilages of children (8-17 years old) with PE (n = 12) and PC (n = 12) and in age-matching autopsy control samples (n = 10) using histological and immunohistochemical staining, atomic force and nonlinear optical microscopy, transmission and scanning electron microscopy, morphometry and statistics.

Results

AT areas were identified in the costal cartilage ECM in children with normal chest, PE and PC. Each type of the AT areas ("canonical", "intertwined", "fine-fibred" and "intralacunary") had a unique morpho

SUBMITTER: Kurkov A 

PROVIDER: S-EPMC7833175 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature