Association of metformin with mortality or ARDS in patients with COVID-19 and type 2 diabetes: A retrospective cohort study.

ABSTRACT:

Aims

To determine the association between metformin use and mortality and ARDS incidence in patients with COVID-19 and type 2 diabetes.

Methods

This study was a multi-center retrospective analysis of COVID-19 patients with type 2 diabetes and admitted to four hospitals in Hubei province, China from December 31st, 2019 to March 31st, 2020. Patients were divided into two groups according to their exposure to metformin during hospitalization. The outcomes of interest were 30-day all-cause mortality and incidence of ARDS. We used mixed-effect Cox model and random effect logistic regression to evaluate the associations of metformin use with outcomes, adjusted for baseline characteristics.

Results

Of 328 patients with COVID-19 and type 2 diabetes included in the study cohor

SUBMITTER: Jiang N 

PROVIDER: S-EPMC7833191 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature