Modeling the Influenza A NP-vRNA-Polymerase Complex in Atomic Detail.

ABSTRACT: Seasonal flu is an acute respiratory disease that exacts a massive toll on human populations, healthcare systems and economies. The disease is caused by an enveloped Influenza virus containing eight ribonucleoprotein (RNP) complexes. Each RNP incorporates multiple copies of nucleoprotein (NP), a fragment of the viral genome (vRNA), and a viral RNA-dependent RNA polymerase (POL), and is responsible for packaging the viral genome and performing critical functions including replication and transcription. A complete model of an Influenza RNP in atomic detail can elucidate the structural basis for viral genome functions, and identify potential targets for viral therapeutics. In this work we construct a model of a complete Influenza A RNP complex in atomic detail using multiple sources of struct

SUBMITTER: Miner JC 

PROVIDER: S-EPMC7833383 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature