Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope.

ABSTRACT: Solving the structure of an antibody-antigen complex gives atomic level information of the interactions between an antibody and its antigen, but such structures are expensive and hard to obtain. Alternative experimental sources include epitope mapping and binning experiments, which can be used as a surrogate to identify key interacting residues. However, their resolution is usually not sufficient to identify if two antibodies have identical interactions. Computational approaches to this problem have so far been based on the premise that antibodies with similar sequences behave similarly. Such approaches will fail to identify sequence-distant antibodies that target the same epitope. Here, we present Ab-Ligity, a structure-based similarity measure tailored to antibody-antigen interfaces. Usi

SUBMITTER: Wong WK 

PROVIDER: S-EPMC7833755 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature