Hypothesis-based food, feed, and environmental safety assessment of GM crops: A case study using maize event DP-202216-6.

ABSTRACT: Event DP-2Ø2216-6 (referred to as DP202216 maize) was genetically modified to increase and extend the expression of the introduced zmm28 gene relative to endogenous zmm28 gene expression, resulting in plants with enhanced grain yield potential. The zmm28 gene expresses the ZMM28 protein, a MADS-box transcription factor. The safety assessment of DP202216 maize included an assessment of the potential hazard of the ZMM28 protein, as well as an assessment of potential unintended effects of the genetic insertion on agronomics, composition, and nutrition. The history of safe use (HOSU) of the ZMM28 protein was evaluated and a bioinformatics approach was used to compare the deduced amino acid sequence of the ZMM28 protein to databases of known allergens and toxins. Based on H

SUBMITTER: Anderson JA 

PROVIDER: S-EPMC7833765 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature