Ontology highlight
ABSTRACT:
SUBMITTER: Peng Z
PROVIDER: S-EPMC7833766 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Peng Zhenzi Z Liu Cuiwei C Victor Aaron R AR Cao Duo-Yao DY Veiras Luciana C LC Bernstein Ellen A EA Khan Zakir Z Giani Jorge F JF Cui Xiaojiang X Bernstein Kenneth E KE Okwan-Duodu Derick D
Oncoimmunology 20210120 1
Granulocytes are key players in cancer metastasis. While tumor-induced <i>de novo</i> expansion of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the fate and contribution of terminally differentiated mature neutrophils to the metastatic process remain poorly understood. Here, we show that in experimental metastatic cancer models, CXCR4<sup>hi</sup>CD62L<sup>lo</sup> aged neutrophils accumulate via disruption of neutrophil circadian homeostasis and direct stimulati ...[more]