The emerging role and significance of circular RNAs in viral infections and antiviral immune responses: possible implication as theranostic agents.

ABSTRACT: Circular RNAs (circRNAs) are ubiquitously expressed, covalently closed rings, produced by pre-mRNA splicing in a reversed order during post-transcriptional processing. Circularity endows 3'-5'-linked circRNAs with stability and resistance to exonucleolytic degradation which raises the question whether circRNAs may be relevant as potential therapeutic targets or agents. High stability in biological systems is the most remarkable property and a major criterion for why circRNAs could be exploited for a range of RNA-centred medical applications. Even though various biological roles and regulatory functions of circRNAs have been reported, their in-depth study is challenging because of their circular structure and sequence-overlap with linear mRNA counterparts. Moreover, little is known about th

SUBMITTER: Awan FM 

PROVIDER: S-EPMC7833768 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature