Human endeavor for anti-SARS-CoV-2 pharmacotherapy: A major strategy to fight the pandemic.

ABSTRACT: The global spread of COVID-19 constitutes the most dangerous pandemic to emerge during the last one hundred years. About seventy-nine million infections and more than 1.7 million death have been reported to date, along with destruction of the global economy. With the uncertainty evolved by alarming level of genome mutations, coupled with likelihood of generating only a short lived immune response by the vaccine injections, the identification of antiviral drugs for direct therapy is the need of the hour. Strategies to inhibit virus infection and replication focus on targets such as the spike protein and non-structural proteins including the highly conserved RNA-dependent-RNA-polymerase, nucleotidyl-transferases, main protease and papain-like proteases. There is also an indirect option to ta

SUBMITTER: Wang R 

PROVIDER: S-EPMC7834004 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature