Reprogramming of m⁶A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.

ABSTRACT: Hypoxia causes a series of responses supporting cells to survive in harsh environments. Substantial post-transcriptional and translational regulation during hypoxia has been observed. However, detailed regulatory mechanism in response to hypoxia is still far from complete. RNA m⁶A modification has been proven to govern the life cycle of RNAs. Here, we reported that total m⁶A level of mRNAs was decreased during hypoxia, which might be mediated by the induction of m⁶A eraser, ALKBH5. Meanwhile, expression levels of most YTH family members of m⁶A readers were systematically down-regulated. Transcriptome-wide analysis of m⁶A revealed a drastic reprogramming of m⁶A epitranscriptome during cellular hypoxia. Integration of m^6<

SUBMITTER: Wang YJ 

PROVIDER: S-EPMC7834094 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature