Pathophysiology of COVID-19-associated acute respiratory distress syndrome: a multicentre prospective observational study.

ABSTRACT:

Background

Patients with COVID-19 can develop acute respiratory distress syndrome (ARDS), which is associated with high mortality. The aim of this study was to examine the functional and morphological features of COVID-19-associated ARDS and to compare these with the characteristics of ARDS unrelated to COVID-19.

Methods

This prospective observational study was done at seven hospitals in Italy. We enrolled consecutive, mechanically ventilated patients with laboratory-confirmed COVID-19 and who met Berlin criteria for ARDS, who were admitted to the intensive care unit (ICU) between March 9 and March 22, 2020. All patients were sedated, paralysed, and ventilated in volume-control mode with standard ICU ventilators. Static respiratory system compliance, the ratio of partial pre

SUBMITTER: Grasselli G 

PROVIDER: S-EPMC7834127 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature