Corticosteroid Therapy Is Associated With Improved Outcome in Critically Ill Patients With COVID-19 With Hyperinflammatory Phenotype.

ABSTRACT:

Background

Corticosteroid therapy is used commonly in patients with COVID-19, although its impact on outcomes and which patients could benefit from corticosteroid therapy are uncertain.

Research question

Are clinical phenotypes of COVID-19 associated with differential response to corticosteroid therapy?

Study design and methods

Critically ill patients with COVID-19 from Tongji Hospital treated between January and February 2020 were included, and the main exposure of interest was the administration of IV corticosteroids. The primary outcome was 28-day mortality. Marginal structural modeling was used to account for baseline and time-dependent confounders. An unsupervised machine learning approach was carried out to identify phenotypes of COVID-19.

Results

A total

SUBMITTER: Chen H 

PROVIDER: S-EPMC7834518 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature