Improving SARS-CoV-2 structures: Peer review by early coordinate release.

ABSTRACT: This work builds upon the record-breaking speed and generous immediate release of new experimental three-dimensional structures of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and complexes, which are crucial to downstream vaccine and drug development. We have surveyed those structures to catch the occasional errors that could be significant for those important uses and for which we were able to provide demonstrably higher-accuracy corrections. This process relied on new validation and correction methods such as CaBLAM and ISOLDE, which are not yet in routine use. We found such important and correctable problems in seven early SARS-CoV-2 structures. Two of the structures were soon superseded by new higher-resolution data, confirming our proposed changes. For th

SUBMITTER: Croll TI 

PROVIDER: S-EPMC7834719 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature