A novel immune-related genes prognosis biomarker for hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is closely associated with the immune microenvironment. To identify the effective population before administering treatment, the establishment of prognostic immune biomarkers is crucial for early HCC diagnosis and treatment.

Results

A total of 335 IRGs identified from 788 overlapping IRGs were associated with the survival of HCC. A prognostic immunoscore model was identified. The Kaplan-Meier survival curves and time-dependent ROC analysis revealed a powerful prognostic performance of immunoscore signature via multi validation. Besides, the immunoscore signature exhibited a better predictive power compared to other prognostic signatures. Gene set enrichment analysis showed multiple signaling differences between the high and low immun

SUBMITTER: Wang K 

PROVIDER: S-EPMC7834986 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature