Accumulation of LOX-1⁺ PMN-MDSCs in nasopharyngeal carcinoma survivors with chronic hepatitis B might permit immune tolerance to epstein-barr virus and relate to tumor recurrence.

ABSTRACT: Chronic hepatitis B (CHB) has been reported to be associated with impaired prognosis for patients with nasopharyngeal carcinoma (NPC). However, the latent mechanism is unclear. Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) induce immune suppression in CHB and promote the development of hepatocellular carcinoma. Lectin-type oxidized LDL receptor-1 (LOX-1) was recently identified as a specific marker for PMN-MSDC. We found NPC survivors with CHB had high levels of LOX-1⁺ PMN-MDSCs. LOX-1⁺ PMN-MDSCs significantly reduced T cell proliferation and activation. Endoplasmic reticulum stress was induced in LOX-1⁺ PMN-MDSCs. In addition, LOX-1⁺ PMN-MDSCs increased their expression of NOX2, a key reactive oxygen species (ROS)-related genes,

SUBMITTER: Li X 

PROVIDER: S-EPMC7834990 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature